Blar i forfatter "Kyrrestad, Ingelin"
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Cytomegalovirus infection and dexamethasone effects in liver sinusoidal endothelial cells
Kyrrestad, Ingelin (Doctoral thesis; Doktorgradsavhandling, 2024-03-15)The liver is a major organ in the body's defense against blood-borne pathogens. It acts as a filter for the blood and is a central site for immune responses, and a central hub for various metabolic processes. Within the liver, an extensive network of small blood vessels, the hepatic sinusoids, are key sites for the exchange of nutrients and waste products between the blood circulation and the liver ... -
Protocol for Isolation and Culture of Mouse Hepatocytes (HCs), Kupffer Cells (KCs), and Liver Sinusoidal Endothelial Cells (LSECs) in Analyses of Hepatic Drug Distribution
Elvevold, Kjetil; Kyrrestad, Ingelin; Smedsrød, Bård (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-25)Development of the new generation of drugs (e.g., oligo- and polynucleotides administered intravascularly either as free compounds or as nano-formulations) frequently encounters major challenges such as lack of control of targeting and/or delivery. Uncontrolled or unwanted clearance by the liver is a well-known and particularly important hurdle in this respect. Hence, reliable techniques are needed ...